Developing an approach for assigning GRADE levels in a systematic overview of reviews of diagnostic test accuracy using general principles identified from current GRADE guidelines: A case study

This is a research article detailing the application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to complex evidence syntheses such as umbrella reviews and overviews of reviews. 

Date of publication: 13 Oct 2025
Authors: Andrew Dullea, Lydia O'Sullivan, Kirsty O'Brien, Patricia Harrington, Marie Carrigan, Susan Ahern, Maeve McGarry, Karen Cardwell, Michelle O’Neill, Kieran A. Walsh, Barbara Clyne, Susan M. Smith, Máirín Ryan
Journal: Research Synthesis Methods
Digital object identifier: 10.1017/rsm.2025.10047
Type of output: Original Research
Suggested Citation:

Dullea A, O’Sullivan L, O’Brien KK, et al. Developing an approach for assigning GRADE levels in a systematic overview of reviews of diagnostic test accuracy using general principles identified from current GRADE guidelines: A case study. Research Synthesis Methods. Published online 2025:1-12. doi:10.1017/rsm.2025.10047